The Feinstein Institute for Medical Research
Thursday, June 16th 12:00 - 12:30 UTC+2
One of the major goals of our laboratory is to understand how erythropoiesis is regulated and how perturbations in this program lead to anemia. Indeed, different regulated pathways coexist leading to the formation of a functional red cell with a properly assembled membrane and a defined hemoglobin concentration. During development, these events are differentially regulated, and this is one of the main focuses of my lab. Our laboratory is also very involved in translational studies, notably in the reactivation of Fetal-hemoglobin for the treatment of sickle cell disease and getting a better understand the erythropoietic failure leading to red cell aplasia in Diamond Blackfan anemia and other bone marrow failure syndromes. More recently, we took interest in anemia of inflammation and its impact on erythroblastic islands. We use different mouse models and in vitro culture systems in order to fully explore normal and disordered erythropoiesis.